Millennium Pain Center Leaders in Pain Control, Research, Education and Advocacy.
  • Previous Clinical Research Trials

    CLINICAL RESEARCH EXPERIENCE

     

    Abbott Laboratories.  A Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of ABT-894, Duloxetine and Placebo in Subjects with Diabetic Neuropathic Pain. 2007

     

    Advanced Bionics, A Boston Scientific Company. Spinal Neuromodulation in the Treatment of Discogenic Low Back Pain.2006

     

    Advanced Bionics, A Boston Scientific Company Effectiveness of the Precision® Spinal Cord Stimulation System in Patients with FBSS and Axial low Back Pain.  2005

     

    Advanced Neuromodulation Systems. A Clinical Evaluation of the Eon™ 16-Channel Implantable Pulse Generator (IPG) in combination with two Octrode® (8 contact) leads for the management of chronic back pain with or without neuropathic leg pain. 2006

     

    Allergan Sales Inc. A Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel-group Study of the Safety and Efficacy of a Single treatment of AGN-214868 in Patients With Postherpetic Neuralgia. 2013

     

    AstraZeneca  A Phase IIa, Double-Blind, Randomised, Parallel-Group, Multi-Centre Study to Evaluate the Analgesic Efficacy of 28 Days Oral Administration of AZD2066 with One-Dose Escalation Compared to Placebo in Peripheral Neuropathic Pain Patients with Mechanical Hypersensitivity.2009

     

    AstraZeneca. A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC). 2008

     

    BioDelivery Systems International A 12-Week, Placebo-Controlled, Double-Blind, Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BEMA® Buprenorphine in Subjects With Moderate to Severe Low Back Pain. 2010

     

    BioDelivery Systems International A 52-week, Open-Label, Long-Term Treatment Evaluation of the Safety and Efficacy of BEMA® Buprenorphine in Subjects With Moderate to Severe Chronic Pain. 2011

     

    Biogen A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study using a Bayesian Adaptive Design to Assess the Efficacy, Safety, Tolerability, and Serum Exposure of Multiple Doses of BG00010 (Neublastin) in Subjects with Painful Lumbar Radiculopathy 2014

     

    Bioness, Inc. Prospective, Multi-Center, Randomized, Double-Blinded, Partial-Crossover Study to Assess the Safety and Efficacy of the Bioness® Stimrouter™ Neuromodulation System in the Treatment for Patients with Chronic Pain of Peripheral Nerve Origin. 2012

     

    Boston Scientific. Precision Plus High-Rate Subperception Spinal Cord Stimulation for the Treatment of Chronic Intractable Pain. 2005

     

    Boston Scientific. Multiple Areas of Pain (MAP), Epidemiology of Multisite Pain in the Chronic Pain Population. 2012

     

    Boston Scientific Spinal Cord Stimulation with Precision® SCS System versus Reoperation, EVIDENCE. 2010

     

    Cephalon  A Randomized, Double-Blind, Active-Controlled Crossover Study to Evaluate the Efficacy and Safety of Fentanyl Buccal Tablets Compared With Immediate-Release Oxycodone for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Chronic Pain Followed by a 12-Week Open-Label Extension to Evaluate the Impact of Fentanyl Buccal Tablets on Patient Outcomes. 2008

     

    Cephalon  A Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Study to Evaluate the Safety and Efficacy of CEP-37247 Administered at Single Doses of 0.5, 1, 3, 6, or 12 mg by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation. 2010

     

    Cephalon. A 12 Week, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate

    the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release tablets (CEP-33237) at 15 to 90 mg Every 12 hours for Relief of Moderate to Severe Pain in Patients with Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time. 2010

     

    Cephalon. A 4-Week Open-Label Study to Evaluate the Effect of Treatment With Fentanyl Buccal Tablets on Pain Anxiety Symptoms When Used for the Management of Breakthrough Pain in Opioid-Tolerant Patients with Chronic Pain. 2006

     

    Cephalon.  A 12-Month, Open-Label Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) at 15 to 90 mg Every 12 Hours in Patients Who Require Opioid Treatment for an Extended Period of Time. 2006

     

    CNS Therapeutics, Inc. A Phase 3, Open-Label, Single-Arm Study To Assess The Safety Of Hydromorphone Hydrochloride Delivered By Intrathecal Administration. 2013

     

    Cubist Pharmaceuticals, Inc. A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Long-term Safety and Tolerability of CB-5945 for the Treatment of Opioid-Induced Constipation in adults Taking Opioid Therapy for Chronic Non-Cancer Pain. 2012

     

    Depomed. A Phase III Multicenter, Randomized, Double-Blind, Placebo-Controlled study of the Safety and Efficacy of Gabapentin Extended release (G-ER) Tablets in the Treatment of Patients with Postherpetic Neuralgia. 2009

     

    Epimed International. A Multi-Center, Prospective, Randomized, Controlled, Single-Blind Evaluation of the Safety and Efficacy of Percutaneous Lumbar Epidural Adhesiolysis in the Treatment of Painful Spinal Stenosis. 2009

     

    EMPI  The E-STIM Trial: A Randomized, Double-Blind, Multicenter Trial Comparing the Efficacy of the Empi SelectTM Transcutaneous Electrical Nerve Stimulation (TENS) to a Control for the Treatment of Chronic Lower Back Pain. 2008

     

    GlaxoSmithKline A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Alvimopan 0.5mg Once Daily and 0.5mg Twice Daily for 12 Weeks for the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid Therapy for Persistent Non-Cancer Pain. 2005

     

    Johnson and Johnson.  Study for the Validation of BF-Diary for Assessing Opioid-Induced Constipation. 2009

     

    Johnson and Johnson. A Randomized, Double-Blind, Placebo-and-Active-Controlled, Parallel-Arm, Multicenter Study in Subjects With End-Stage Joint disease to Compare the Frequency of Constipation Symptoms in Subjects treated With Tapentadol IR and Oxycodone IR Using a Bowel Function Patient Diar 2008

     

    Johnson & Johnson A Randomized, Double-Blind, Placebo- and Oxycodone Immediate Release (IR) – Controlled Study of Tapentadol IR for the Treatment of Acute Pain Caused by Vertebral Compression Fractures Associated With Osteoporosis.  2010

     

    Johnson and Johnson. A Randomized, Double-Blind, Active and Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy and Safety of Multiple Doses of CG5503 Immediate-Release Formulation in Subjects Awaiting Primary Joint Replacement Surgery for End-Stage Joint Disease.  2009

     

    Kimberly-Clark Corporation. A Prospective, Randomized, Multi-Center, Open-Label Clinical Trial Comparing Disc Biacuplasty with Medical Management for Discogenic Lumbar Back Pain.2011

     

    Kimberly-Clark Corporation A Prospective, Double-Blind, Randomized, Control Trial to Compare the Efficacy of Cooled Radiofrequency Ablation vs. Conventional Monopolar Radiofrequency Ablation of the Geniculate Nerve for the Treatment of Chronic Ostearthritic Knee Pain 2014

     

    Kodiak. A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC). 2010

     

    Kodiak. A Randomized, Double-Blind, Placebo-Controlled 12-Week Extension Study to Assess the Safety and Tolerability of NKTR-118 in Patients with Non-Cancer-Related Pain and Opioid-Induced Constipation (OIC). 2011

     

    Medtronic.  Randomized, Double-Blind, Placebo-Controlled, Parallel Dose Response Study of Gabapentin Injection for Intrathecal Administration in Subjects with Chronic, Intractable Pain. 2008

     

    Medtronic  Low Back Pain Outcomes Registry (LoBaPOR). 2006

     

    Medtronic Implantable System Performance Registry (ISPR). 2006

     

    Medtronic. Open-label, Sequential, Dose Escalation Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy 2013

     

    Merck & Co.  A Prospective, Randomized, Double-blind, Multicenter Trial to evaluate Etrocoxib vs. Diclofenac Sodium Gastrointestinal Tolerability and Effectiveness. 2003

     

    Merck & Co.  A Randomized, Double-Blind, Active-Comparator-Controlled, Parallel-Group Study to Evaluate the Safety of Etoricoxib in Patients with Osteoarthritis or Rheumatoid Arthritis (MEDAL study).  2002

     

    Mundipharma Research GmbH & Co.  A confirmatory, placebo-controlled, randomized, double-blind, single-dummy, parallel group, ratio-finding study in constipated pain patients to establish an optimal hydromorphone – naloxone ratio with an improved bowel function and a comparable analgesic efficacy compared to hydromorphone alone. 2011

     

    Nektar Therapeutics. A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Multiple-Dose, Dose, Escalation Study to Evaluate the Efficacy, Safety and Tolerability of NKTR-118 in Patients with Opioid-Induced Constipation (OIC). 2007

     

    NeurogesX, Inc. A Multicenter Randomized, Double-blind, Controlled Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Two Capsaicin Concentration Variations of NGX-1998 (10% or 20% w/w) in Subjects With Postherpetic Neuralgia (PHN). 2010

     

    Nevro Corporation The Nevro Study: Evaluation of Nevro Handheld Stimulator for the Treatment of Back Pain. 2009

     

    Nevro Corporation. Multi-Center, Prospective, Randomized, Controlled Clinical Trial to Demonstrate Non-Inferiority of the Senza™ Spinal Cord Stimulation (SCS) System in the Treatment of Chronic Pain as Compared to Commercially Available SCS Devices. 2012

     

    Orthovita. A Randomized, Controlled Clinical Study to Evaluate the safety and Effectiveness of Cortoss® Synthetic Cortical Bone Void Filler in Vertebral Augmentation. 2006

     

    Pfizer, Inc.  A Phase 3, Multi-Center, Randomized, Double-Blind, Controlled Study of the Long-Term Analgesic Efficacy and Safety of Tanezumab Alone or in Combination with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone in Patients with Osteoarthritis of the Knee or Hip. 2008

     

    Pfizer, Inc. A Phase 3 Randomized, Double-Blind Placebo and Naproxen Controlled Multicenter Study of the Analgesic Efficacy and Safety of Tanezumab in Patients with Osteoarthritis of the Hip or Knee. 2009

     

    Pfizer, Inc. A Phase 3, Multicenter, Randomized, Long-Term Study of the Safety of Tanezumab in Patients with Osteoarthritis of the Knee or Hip. 2009

     

    Pfizer, Inc.  A Randomized, Double Blind, Placebo Controlled, Parallel Group Study of the Efficacy and Safety of Pregabalin (BID) in Subjects with Post-Traumatic Peripheral Neuropathic Pain 2007

     

    Pfizer, Inc. A Phase 3 Double-Blind, Randomized, Placebo-Controlled, Safety and Efficacy Study of Once Daily Controlled Release Pregabalin in the Treatment of Patients with Postherpetic Neuralgia 2013

     

    Purdue Pharma, L.P. A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Active-Controlled, Parallel-Group, Multicenter Trial of Oxycodone/Naloxone Controlled-Release Tablets (OXN) to Assess the Analgesic Efficacy (Compared to Placebo) and the Management of Opioid-Induced Constipation (Compared to Oxycodone Controlled-release Tablets (OXY)) in Opioid-Experienced subjects with Uncontrolled Moderate to Severe Chronic Low Back Pain and a History of Opioid-Induced Constipation who Require Around-the-clock Opioid Therapy. 2012

     

    Seikagaku Corporation. A Multicenter, Randomized, Double-blind, Controlled, Comparative

    Study of SI-6603 in Patients with Lumbar Disc Herniation (PhaseIII) 2013

     

    Shionogi. A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Phase 3 Study to Evaluate the Long-term Safety of Naldemedine for the Treatment of Opioid-induced Constipation in Subjects with Non-malignant Chronic Pain Receiving Opioid Therapy 2014

     

    Spinal Restoration, Inc. A Multicenter, Randomized, Blinded, Saline-Controlled Trial of Resorbable Biologic Disc Augmentation for Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) with the Biostat® System.  2010

     

    Sucampo Open-Labeled Study of the Long Term Safety and Efficacy of Lubiprostone in Patients with Opioid-induced Bowel Dysfunction. 2009

     

    Sucampo. A Multicenter, Randomized, Placebo-controlled, Double-blinded Study of the

    Efficacy and Safety of Lubiprostone in Patients with Opioid-Induced Bowel Dysfunction. 2009

     

    Teva Branded Pharmaceuticals Products R&D, Inc. A 12-Week, Randomized, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Study to Evaluate the Efficacy and Safety of Hydrocodone Bitrartrate Extended-Release Tablets (CEP-33237) at 30 to 90 mg Every 12 Hours for Relief of Moderate to Severe Pain in Patients With Chronic Pain Who Require Opioid Treatment for an Extended Period of Time. 2007

     

    The Alfred Mann Foundation. The Clinical Evaluation of the Implantable Pump System for Safety and Delivery Accuracy in Patients Requiring Intrathecal Administration of Morphine Sulfate for Chronic Pain. 2011

     

    Theravance, Inc. A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of TD-1211 in Subjects with Opioid-Induced Constipation. 2011

     

    Vertos Medical, Inc. mild®Decompression Alternative to Open Surgery Epidural Steroid Injection Comparative Outcomes Study (MiDAS ECO) in Patients Diagnosed with Moderate to Severe Lumbar Spinal Stenosis Exhibiting Neurogenic Claudication. 2014

     

    Wyeth Research. A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of MOA-728 in the Treatment of Opioid Induced Constipation in Patients with

     Non-Malignant Pain. 2008

     

    Mallinckrodt Inc. A Phase 3, Open-Label, Single-Arm Study to Assess the Safety of Hydromorphone Hydrochloride Delivered by Intrathecal Administration.  2013

     

    INVESTIGATOR-INITIATED CLINICAL RESEARCH

    Advanced Bionics, A Boston Scientific Company, and Millennium Pain Center. Paresthesia and Spinal Cord Stimulation: Functional Relevance of Sensory Overlap? 2005

     

    Advanced Bionics, A Boston Scientific Company, and Millennium Pain Center. Spinal Neuromodulation in the Treatment of Chronic Discogenic Low Back Pain. 2006

     

    Boston Scientific, Millennium Pain Center, and Illinois State University, Department of Biological Sciences  Effects of Neuromodulation on Glial Cell Activity.

     

    Millennium Pain Center and Illinois State University, Department of Biological Sciences. Effects of Serotonin Reuptake Inhibitors in the Immune Suppression Mediated by Opiates.

     

    Millennium Pain Center and Illinois State University, Department of Biological Sciences. Effects of Intermittent Versus Continuous Opioid Administration on Cellular and Humoral Immune Responses.

     

    Millennium Pain Center, Bloomington, Illinois. A Prospective, Clinical Trial of the Predictive Value of Sympathetic Blocks and Somatosensory Evoked Potential Testing in successful treatment of Chronic Neuropathic Pain with Spinal Cord Stimulators.

    Millennium Pain Center, Bloomington, Illinois. A Prospective, Randomized, Double-blind controlled Clinical Trial Comparing the Efficacy of Pulse Radiofrequency Lesioning (PRFL) versus Neurolytic Radiofrequency Ablation in the Treatment of Lumbar Facet Syndrome.  2010

     

    Millennium Pain Center, Bloomington, Illinois. Incidence of Intravascular Penetration During Interlaminar Epidural steroid Injections.

     

    Millennium Pain Center, Bloomington, Illinois; Teknon Foundation, Barcelona, Spain 

    A Prospective, Randomized, Controlled, Double-Blind Study to Evaluate the Safety and Efficacy of Pulsed-Radiofrequency Versus Continuous Radiofrequency Neuromodulation

    for the Treatment of Chronic Lower Back Pain Originating from Lumbar Facet Joints. 2008

    Millennium Pain Center and Teknon Foundation.  A Prospective, Randomized, Double-Blind, Cross-Over, Multi-Center Study to Evaluate the Comparative Efficacy of Pulsed-Radiofrequency Neuromodulation of the Dorsal Root Ganglion Versus Transforaminal Lumbar Epidural Steroid Injection for the Treatment of Chronic Radicular Low Back Pain. 2010

     

    Millennium Pain Center, Teknon Foundation, and La MaratÇ’ de TV3 Foundation. A Phase 3, Multi-Center, Randomized, Double-Blind, Controlled Study of the Long-Term Analgesic Efficacy and Safety of Tanezumab Alone or in Combination with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDSs Alone in Patients with Osteoarthritis of the Knee of Hip. 2010